2026 CRBE Summit East - Innovations in Controlled Release, Bioavailability Enhan

The oral administration of macromolecules such as peptides and proteins continues to be limited by harsh gastrointestinal conditions, rapid enzymatic degradation, and poor membrane permeability. Novel delivery technologies—such as sophisticated lipid-based systems, delayed-release softgel platforms, and buccal or sublingual approaches—are emerging to overcome these barriers. By protecting sensitive compounds, directing site-specific release in the intestine, and leveraging lymphatic transport pathways, these solutions aim to enhance systemic exposure. This presentation will highlight the scientific rationale and data demonstrating how these innovations are advancing the clinical feasibility of oral macromolecule delivery. The current state of macromolecule delivery and recent advances in this space will be discussed.