2026 CRBE Summit East - Innovations in Controlled Release, Bioavailability Enhan

Small molecules that belong to BCS II and IV classes pose developability challenges and require formulation strategies to enhance oral bioavailability. This talk will discuss various strategies to overcome this problem. 1) Amorphous solid dispersions (ASDs)- This section will focus on dissolution mechanism of ASDs and strategies (surfactants, pH modifiers) to increase drug load in ASD without comprising dissolution performance. 2) Prodrugs- Considerations for developing prodrugs for rapidly crystallizing compound and impact of pro-moeity selection on prodrug performance will be discussed. 3) Permeation enhancers (PEs) for BCS IV- Utilizing PEs for enhancing oral bioavailability of BCS IV compound and impact of solid form and formulation strategy on performance of the PE will be discussed.