2026 CRBE Summit East - Innovations in Controlled Release, Bioavailability Enhan

Lipid-based emulsions are increasingly used to enhance drug delivery, yet the impact of lipid digestion on permeation outcomes is often overlooked. This session examines how enzymatic digestion transforms emulsions into dynamic colloidal structures—such as mixed micelles and vesicles—that directly influence drug solubilization and transport across biological barriers. We will discuss why conventional in-vitro permeation models, when applied without accounting for digestion processes, may fail to predict in-vivo performance. Key factors including lipid composition, droplet size, bile interactions, and digestion kinetics will be highlighted. Attendees will gain practical insight into designing more biorelevant in-vitro permeation models that better reflect physiological conditions and support informed formulation development.